Jherings Eigentumsbegriff: seine römischrechtlichen Grundlagen und sein Einfluss auf das BGB
In: Berliner Schriften zur Rechtsgeschichte Bd. 5
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In: Berliner Schriften zur Rechtsgeschichte Bd. 5
World Affairs Online
In: Journal of vocational behavior, Band 108, S. 121-131
ISSN: 1095-9084
In: Environmental science and pollution research: ESPR, Band 29, Heft 27, S. 41375-41385
ISSN: 1614-7499
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 188, S. 109858
ISSN: 1090-2414
In: Environmental science and pollution research: ESPR, Band 25, Heft 11, S. 11152-11162
ISSN: 1614-7499
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 165, S. 450-458
ISSN: 1090-2414
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 140, S. 109-115
ISSN: 1090-2414
In: Journal of lesbian studies, Band 21, Heft 1, S. 70-87
ISSN: 1540-3548
In: Journal of GLBT family studies, Band 13, Heft 3, S. 236-256
ISSN: 1550-4298
In: LITHOS10301
SSRN
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/IJN.S42800
Yan Chen,* Ji Sun,* Ying Lu, Chun Tao, Jingbin Huang, He Zhang, Yuan Yu, Hao Zou, Jing Gao, Yanqiang Zhong Department of Pharmaceutical Science, School of Pharmacy, The Second Military Medical University, Shanghai, People's Republic of China *These authors contributed equally to this work Abstract: pH-sensitive liposomes represent an effective gene vector in cancer therapy. However, their use is greatly hampered by their relatively low transfection efficiency. To improve the transfection efficiency of pH-sensitive liposomes, we prepared complexes containing 3β-[N-(N',N'-dimethylaminoethane) carbamoyl] cholesterol (DC-Chol) and dioleoylphosphatidyl ethanolamine (DOPE) liposomes and pH-sensitive liposomes composed of cholesteryl hemisuccinate (CHEMS) and DOPE, and evaluated the influence of various factors on plasmid DNA (pDNA) transfection efficiency. All DC-Chol/DOPE liposome/pDNA and pH-sensitive liposome complexes showed similarly potent pH sensitivity. In the presence of serum-containing medium, two optimized complexes of DC-Chol/DOPE liposomes/pDNA and pH-sensitive PEGylated liposomes showed high transfection efficiency of 22.94% and 20.07%, respectively. Notably, DC-Chol/DOPE (2:3) liposomes/pH-sensitive PEGylated (1%) liposome complexes with a charge ratio of 1:1 (m/m [+/-]) showed enhanced accumulation in tumors in vivo. Our results show the influence of various factors on pDNA transfection efficiency in complexes of DC-Chol/DOPE liposomes and pH-sensitive PEGylated liposomes. Understanding of such mechanisms will lead to better design of complexes of DC-Chol/DOPE liposomes and pH-sensitive liposomes for gene therapy. Keywords: cationic liposomes, pH-sensitive liposomes, pDNA, transfection, PEGylated
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In: BITE-D-21-06744
SSRN
In: Harvard contemporary China series 20
""Adopts an evolutionary framework to examine how the Chinese state relates with non-state actors across several fields of governance: community, environment, public health, economics, labor, society, and religion; identifies areas where state-society interactions have shifted over time, ranging from constructive engagement to protracted conflict, thereby providing nuanced insight into the circumstances wherein the party-state exerts its coercive power versus engaging in more flexible responses"--Provided by publisher"--
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